cis-3-Amino-2-phenylpiperidine

Base Information

• Chemical Name: cis-3-Amino-2-phenylpiperidine
• CAS No.: 160551-72-4
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.261
• Mol file: 160551-72-4.mol

Synonyms:cis-3-Amino-2-phenylpiperidine;

Chemical Property of cis-3-Amino-2-phenylpiperidine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 293.84 °C at 760 mmHg
• PKA: 10.22±0.40(Predicted)
• Flash Point: 152.952 °C
• PSA: 38.05000
• Density: 1.012 g/cm³
• LogP: 2.46750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-3-Amino-2-phenylpiperidine

There total 51 articles about cis-3-Amino-2-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzyl (2R,3S)-2-phenyl-1-[(R)-1-phenylethyl]piperidin-3-ylcarbamate (1032169-25-7) → (2R,3S)-2-phenylpiperidin-3-amine (1032169-90-6,160551-72-4)

Guidance literature:

With hydrogenchloride; 10% Pd on charcoal; hydrogen; In ethanol; water; at 20 ℃; for 12h;

DOI:10.1021/ol800722a

Reference yield: 80.0%

(2R,3R)-1-benzyl-2-phenylpiperidin-3-amine (1448991-06-7) → cis-3-amino-2-phenyl-piperidine (161167-79-9,160551-72-4)

Guidance literature:

With 15 % Pd(OH)2/C; hydrogen; acetic acid; In ethanol; at 60 ℃; for 72h; under 51716.2 Torr; enantioselective reaction;

DOI:10.3987/COM-12-S(N)82

Reference yield: 78.0%

2-phenyl-3-nitropyridine (134896-35-8) → cis-2-phenyl-3-aminopiperidine (160551-72-4)

Guidance literature:

2-phenyl-3-nitropyridine; With hydrogen; platinum(IV) oxide; In methanol; for 2h; under 2327.23 Torr;

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; water; for 6.25h; under 2327.23 Torr;

upstream raw materials:

3-amino-2-phenylpyridine

pyrographite

platinum

2-phenyl-3-nitropyridine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ABNORMAL CELLULAR PROLIFERATION". . . Retrieved 2019/07/20.
• 2、 Iimuro, Atsuhiro,Higashida, Kosuke,Kita, Yusuke,Mashima, Kazushi. "Asymmetric Hydrogenation of 3-Amido-2-arylpyridinium Salts by Triply Chloride-Bridged Dinuclear Iridium Complexes Bearing Enantiopure Diphosphine Ligands: Synthesis of Neurokinin-1 Receptor Antagonist Derivatives". . p. 1929 - 1933. Retrieved 2016/07/06.