benzo[c][1,2]oxaborole-1,6(3H)-diol

Base Information

• Chemical Name: benzo[c][1,2]oxaborole-1,6(3H)-diol
• CAS No.: 1196473-37-6
• Molecular Formula: C₇H₇BO₃
• Molecular Weight: 149.942
• Mol file: 1196473-37-6.mol

Synonyms:6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Chemical Property of benzo[c][1,2]oxaborole-1,6(3H)-diol

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzo[c][1,2]oxaborole-1,6(3H)-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzo[c][1,2]oxaborole-1,6(3H)-diol

There total 15 articles about benzo[c][1,2]oxaborole-1,6(3H)-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

6-methoxybenzo[c][1,2]oxaborol-1(3H)-ol (947163-26-0) → 6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1196473-37-6)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 - 20 ℃;

DOI:10.1016/j.bmcl.2011.02.024

Reference yield: 98.0%

6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1222010-47-0) → 6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1196473-37-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield: 25.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-hydroxyphenylboronic acid (87199-18-6) → 6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1196473-37-6)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 40 ℃; for 20h; Schlenk technique; Inert atmosphere; Sealed tube;

upstream raw materials:

6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

6-methoxybenzo[c][1,2]oxaborol-1(3H)-ol

2-(2-bromo-4-fluorophenyl)-1,3-dioxolane

C₁₆H₁₅BrO₃

Downstream raw materials:

6-(4'-fluoro)benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

6-(2-nitrobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

1,3-dihydro-1-hydroxy-2,2-benzoxaborol-6-yl N-phenylcarbamate

Refernces

• 1、 -. "Preparation method of phenylboronic acid half ester". Paragraph 0010; 0017. . Retrieved 2020/06/09.
• 2、 -. "1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS". Page/Page column 37. . Retrieved 2014/10/03.