Technology Process of (-)-dehydromitragynine
There total 9 articles about (-)-dehydromitragynine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid; trifluoroacetic anhydride;
In
dichloromethane;
at 20 ℃;
for 17h;
Inert atmosphere;
DOI:10.1039/c2cc37023a
- Guidance literature:
-
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: silver trifluoromethanesulfonate / dichloromethane / 20 h / 20 °C / Inert atmosphere
1.2: 0.75 h / 75 °C / Inert atmosphere
2.1: 1,2-bis-(diphenylphosphino)ethane; N-ethyl-N,N-diisopropylamine; caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)) / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere
3.2: 2 h / -78 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 17 h / 20 °C / Inert atmosphere
With
bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; silver trifluoromethanesulfonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; 1,2-bis-(diphenylphosphino)ethane;
In
tetrahydrofuran; dichloromethane;
2.1: |Tsuji-Trost Allylation / 3.1: |Wittig Olefination;
DOI:10.1039/c2cc37023a
