2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 470670-74-7
• Molecular Formula: C₂₄H₁₇NO₅
• Molecular Weight: 399.403
• Mol file: 470670-74-7.mol

Synonyms:2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenyl-oxazolidine-2,5-dione (5840-78-8) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester (470670-74-7)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; at -25 - 20 ℃;

DOI:10.1021/ol026660l

Reference yield:

2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester (470670-74-7) → N-Fmoc-D-phenylglycine (111524-95-9,163883-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (DHQD)2AQN; 4 Angstroem molecular sieves / diethyl ether / 1 h / 23 °C

2: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 0.17 h / 23 °C

With morpholine; hydroquinidine anthraquinone-1,4-diyl diether; 4 A molecular sieve; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ol026660l

Reference yield:

allyl alcohol (107-18-6) + 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester (470670-74-7) → (S)-allyl-(N-9-fluorenylmethoxycarbonyl)phenylglycinate + (R)-allyl-(N-9-fluorenylmethoxycarbonyl)phenylglycinate

Guidance literature:

With hydroquinidine anthraquinone-1,4-diyl diether; 4 A molecular sieve; In diethyl ether; at 23 ℃; for 1h; Title compound not separated from byproducts.;

DOI:10.1021/ol026660l

upstream raw materials:

4-phenyl-oxazolidine-2,5-dione

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

N-Fmoc-D-phenylglycine

Refernces