Technology Process of (R)-methyl 5-(4-fluorophenyl)-6-isopropyl-2-(3-methylpiperazin-1-yl)nicotinate
There total 10 articles about (R)-methyl 5-(4-fluorophenyl)-6-isopropyl-2-(3-methylpiperazin-1-yl)nicotinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
2.1: sodium hydroxide; water / ethanol / 120 °C
2.2: pH < 6
3.1: thionyl chloride / 2.5 h / 20 °C / Reflux
4.1: trifluoroacetic acid / Reflux
With
thionyl chloride; water; potassium carbonate; trifluoroacetic acid; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux
2.1: triethylamine / dmap / dichloromethane / 2.5 h / 0 - 20 °C
3.1: triethylamine / acetonitrile / 0.75 h / 175 °C / Microwave irradiation
4.1: triethylamine / tetrahydrofuran / 4 h / 0 °C
5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere; Microwave irradiation
6.1: sodium hydroxide; water / ethanol / 120 °C
6.2: pH < 6
7.1: thionyl chloride / 2.5 h / 20 °C / Reflux
8.1: trifluoroacetic acid / Reflux
With
N-Bromosuccinimide; thionyl chloride; water; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide;
dmap; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;