C₁₅H₁₃F₅NO₃

Base Information

• Chemical Name: C₁₅H₁₃F₅NO₃
• CAS No.: 76893-15-7
• Molecular Formula: C₁₅H₁₃F₅NO₃
• Molecular Weight: 350.265
• Mol file: 76893-15-7.mol

Synonyms:C₁₅H₁₃F₅NO₃

Chemical Property of C₁₅H₁₃F₅NO₃

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₅H₁₃F₅NO₃

There total 1 articles about C₁₅H₁₃F₅NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 3-carboxy-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy (2154-67-8,46147-16-4) → C15H13F5NO3 (76893-15-7)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; for 3h; Ambient temperature;

DOI:10.1055/s-1980-29268

Reference yield:

C15H13F5NO3 (76893-15-7) → 3-(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidinyl-1-oxy (27298-75-5) + (2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol (55738-75-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 6h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1055/s-1980-29268

Reference yield:

C15H13F5NO3 (76893-15-7) → C17H15F5NO3 (76893-23-7)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / ethanol / 6 h / Ambient temperature

2: 83 percent / MnO₂ / CCl₄ / 0.5 h / Heating

3: 52 percent / Piperidine / pyridine / 5 h / 100 °C

4: 62 percent / Dicyclohexylcarbodiimide / ethyl acetate / 3 h / Ambient temperature

With manganese(IV) oxide; sodium tetrahydroborate; dicyclohexyl-carbodiimide; piperidine; In pyridine; tetrachloromethane; ethanol; ethyl acetate;

DOI:10.1055/s-1980-29268

upstream raw materials:

2,3,4,5,6-pentafluorophenol

3-carboxy-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy

Downstream raw materials:

3-(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidinyl-1-oxy

(2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol

3-formyl-2,2,5,5-tetramethyl-pyrroline-1-oxyl

C₁₁H₁₈NO₂

Refernces