Technology Process of tert-Butyl-((2E,6E,10E,14E)-3,7,11,15,19-pentamethyl-icosa-2,6,10,14,18-pentaenyloxy)-diphenyl-silane
There total 8 articles about tert-Butyl-((2E,6E,10E,14E)-3,7,11,15,19-pentamethyl-icosa-2,6,10,14,18-pentaenyloxy)-diphenyl-silane which
guide to synthetic route it.
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synthetic route:
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145014-11-5
tert-Butyl-((2E,6E,10E,14E)-3,7,11,15,19-pentamethyl-icosa-2,6,10,14,18-pentaenyloxy)-diphenyl-silane
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1) lithium biphenylide, barium iodide / 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1.5 h, b) room temperature, 16 h
2: 1) lithium biphenylide, barium iodide / 1) THF, -78 deg C, 30 min, 2) THF, a) -78 deg C, 1.5 h, b) room temperature, 16 h
With
lithium biphenylide; barium(II) iodide;
DOI:10.1016/S0040-4039(00)79008-3
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145014-11-5
tert-Butyl-((2E,6E,10E,14E)-3,7,11,15,19-pentamethyl-icosa-2,6,10,14,18-pentaenyloxy)-diphenyl-silane
- Guidance literature:
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(2E,6E)-farnesyl chloride;
With
lithium biphenylide; barium(II) iodide;
In
tetrahydrofuran;
at -78 ℃;
(Δ2,3E,Δ6,7E)-8-bromo-1-O-tert-butyldiphenylsilyl-3,7-dimethyl-octa-2,6-dien-1-ol;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1021/ol048212e
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145014-11-5
tert-Butyl-((2E,6E,10E,14E)-3,7,11,15,19-pentamethyl-icosa-2,6,10,14,18-pentaenyloxy)-diphenyl-silane
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: Et3N / CH2Cl2 / 1 h / -40 °C
2.1: 1.34 g / LiBr / tetrahydrofuran / 1 h / 0 °C
3.1: lithium biphenylide; BaI2 / tetrahydrofuran / -78 °C
3.2: tetrahydrofuran / -78 - 20 °C
With
lithium biphenylide; barium(II) iodide; triethylamine; lithium bromide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol048212e