Technology Process of 1-(benzenesulfonyl)-3-(α-hydroxyprenyl)indole
There total 6 articles about 1-(benzenesulfonyl)-3-(α-hydroxyprenyl)indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 34 percent / diethyl ether / 2 h / Ambient temperature
2: 1.) trtra-n-butylammonium bisulfate, 50percent aq. NaOH / 1.) benzene, RT, 5 min, 2.) 0.5 h
3: 83 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C
With
sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00362a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / bis(triphenylphosphine)nickel dichloride, methylmagnesium iodide / benzene; diethyl ether / 15 h / Heating
2: 34 percent / diethyl ether / 2 h / Ambient temperature
3: 1.) trtra-n-butylammonium bisulfate, 50percent aq. NaOH / 1.) benzene, RT, 5 min, 2.) 0.5 h
4: 83 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C
With
sodium hydroxide; bis(triphenylphosphine)nickel(II) chloride; lithium aluminium tetrahydride; methyl magnesium iodide; tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jo00362a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) tetra-n-butylammonium bisulfate, 50percent KOH / 1.) benzene, 5 min, 2.) 2 h
2: 1.) a) tert-butyllithium, b) cuprous cyanide / 1.) pentane, THF-Et2O 3:1, a) -95 deg C, 6 min, b) 3 min, 2.) a) -95 deg C, 0.5 h, b) -78 deg C, 1 h, c) RT, 14 h
3: 83 percent / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C
With
potassium hydroxide; lithium aluminium tetrahydride; tert.-butyl lithium; tetra(n-butyl)ammonium hydrogensulfate; copper(l) cyanide;
In
tetrahydrofuran;
DOI:10.1021/jo00362a031
