(S)-3-Amino-3-phenyl propionic acid methylester HCl

Base Information

• Chemical Name: (S)-3-Amino-3-phenyl propionic acid methylester HCl
• CAS No.: 144494-72-4
• Molecular Formula: C₁₀H₁₄NO₂*Cl
• Molecular Weight: 215.68
• Mol file: 144494-72-4.mol

Synonyms:Benzenepropanoicacid, b-amino-, methyl ester,hydrochloride, (S)-;Benzenepropanoic acid, b-amino-, methyl ester, hydrochloride, (bS)- (9CI);(betaS)-beta-Aminobenzenepropanoic acid methyl ester hydrochloride;

Chemical Property of (S)-3-Amino-3-phenyl propionic acid methylester HCl

Chemical Property:

• Vapor Pressure: 0.000283mmHg at 25°C
• Boiling Point: 317.4 °C at 760 mmHg
• Flash Point: 145.8 °C
• PSA: 52.32000
• LogP: 2.75180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

(S)-beta3-Phenylalanine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Amino-3-phenyl propionic acid methylester HCl

There total 6 articles about (S)-3-Amino-3-phenyl propionic acid methylester HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-Amino-3-phenylpropionic acid (3646-50-2) → methyl 3-amino-3-phenylpropionate hydrochloride (22838-46-6,88831-43-0,127022-80-4,144494-72-4)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 20h;

DOI:10.1002/chem.202005351

Reference yield: 98.0%

3-Amino-3-phenylpropionic acid (3646-50-2) → methyl 3-amino-3-phenylpropionate hydrochloride (22838-46-6,88831-43-0,127022-80-4,144494-72-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃;

DOI:10.1002/hlca.200790057

Reference yield:

3-(2-methyl-propane-2-sulfinylamino)-3-phenyl-propionic acid methyl ester (1174169-22-2) → methyl 3-amino-3-phenylpropionate hydrochloride (22838-46-6,88831-43-0,127022-80-4,144494-72-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.75h;

upstream raw materials:

3-Amino-3-phenylpropionic acid

methanol

benzaldehyde

3-(2-methyl-propane-2-sulfinylamino)-3-phenyl-propionic acid methyl ester

Downstream raw materials:

3-Amino-N-hexyl-3-phenyl-propionamide; hydrochloride

3-Phenyl-3-{2-[4-((E)-styryl)-phenoxy]-acetylamino}-propionic acid methyl ester

3-(2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenoxy}-acetylamino)-3-phenyl-propionic acid methyl ester

3-Phenyl-3-{2-[4-((E)-styryl)-phenoxy]-propionylamino}-propionic acid methyl ester

Refernces

• 1、 Kim, Mahn-Joo,Choi, Eunjeong,Kim, Yunwoong,Ahn, Yangsoo,Park, Jaiwook. "Highly enantioselective enzymatic resolution of aromatic β-amino acid amides with Pd-catalyzed racemization". . p. 1449 - 1452. Retrieved 2013/12/04.
• 2、 -. "BETA-AMINO ACID DERIVATIVES FOR TREATMENT OF DIABETES". Page/Page column 43. . Retrieved 2009/09/05.