1-(Diphenylmethyl)pyrrolidine

Base Information

• Chemical Name: 1-(Diphenylmethyl)pyrrolidine
• CAS No.: 6622-08-8
• Molecular Formula: C17H19 N
• Molecular Weight: 237.345
• NSC Number: 406121,56475
• DSSTox Substance ID: DTXSID40288542
• Nikkaji Number: J2.176.556B
• Wikidata: Q82024994
• Mol file: 6622-08-8.mol

Synonyms:1-benzhydrylpyrrolidine;1-(diphenylmethyl)pyrrolidine;6622-08-8;NSC56475;SCHEMBL2054235;DTXSID40288542;DJMXWKUBTGMKCG-UHFFFAOYSA-N;NSC-56475;NSC406121;NSC-406121

Chemical Property of 1-(Diphenylmethyl)pyrrolidine

Chemical Property:

• Vapor Pressure: 0.000224mmHg at 25°C
• Boiling Point: 325.9°Cat760mmHg
• Flash Point: 137.1°C
• Density: 1.069g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 237.151749610
• Heavy Atom Count: 18
• Complexity: 214

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)C(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(Diphenylmethyl)pyrrolidine

There total 17 articles about 1-(Diphenylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(1'-phenyl-1'-selenoxomethyl)pyrrolidine (132637-67-3) + phenyllithium (591-51-5) → 1-[(diphenyl)methyl]pyrrolidine (6622-08-8)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1246/cl.1990.2053

Reference yield: 90.0%

pyrrolidine (123-75-1) + benzaldehyde (100-52-7) + phenyllithium (591-51-5) → 1-[(diphenyl)methyl]pyrrolidine (6622-08-8)

Guidance literature:

pyrrolidine; benzaldehyde; With lithium perchlorate; In dichloromethane; at 20 ℃; for 0.0833333h;

phenyllithium; With lithium perchlorate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1007/s00706-003-0093-2

Reference yield: 88.0%

1-benzhydryl-pyrrolidine 1-oxide → 1-[(diphenyl)methyl]pyrrolidine (6622-08-8)

Guidance literature:

With polymethylhydrosiloxane; palladium on activated charcoal; In ethanol; at 20 ℃;

DOI:10.1055/s-2002-19751

upstream raw materials:

1-(1'-phenyl-1'-selenoxomethyl)pyrrolidine

phenyllithium

pyrrolidine

diphenylchloromethane

Downstream raw materials:

benzophenone

Refernces

• 1、 Muralirajan, Krishnamoorthy,Kancherla, Rajesh,Rueping, Magnus. "Dehydrogenative Aromatization and Sulfonylation of Pyrrolidines: Orthogonal Reactivity in Photoredox Catalysis". supporting information. p. 14787 - 14791. Retrieved 2018/10/20.
• 2、 Xie, Lan-Gui,Dixon, Darren J.. "Tertiary amine synthesis: Via reductive coupling of amides with Grignard reagents". . p. 7492 - 7497. Retrieved 2017/10/30.