Technology Process of (E)-methyl 1-(2-(4-cyanophenyl)-1-iodovinyl)-1H-indole-3-carboxylate
There total 4 articles about (E)-methyl 1-(2-(4-cyanophenyl)-1-iodovinyl)-1H-indole-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 1-((4-cyanophenyl)ethynyl)-1H-indole-3-carboxylate;
With
trimethylsilyl iodide;
In
dichloromethane;
at -20 ℃;
for 0.25h;
Inert atmosphere;
With
water;
In
dichloromethane;
at 20 ℃;
for 0.833333h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tetlet.2013.03.107
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere
2.1: trimethylsilyl iodide / dichloromethane / 0.25 h / -20 °C / Inert atmosphere
2.2: 0.83 h / 20 °C / Inert atmosphere
With
1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl iodide; potassium carbonate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2013.03.107
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere
2.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / tetrahydrofuran / 80 °C / Inert atmosphere
3.1: trimethylsilyl iodide / dichloromethane / 0.25 h / -20 °C / Inert atmosphere
3.2: 0.83 h / 20 °C / Inert atmosphere
With
N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl iodide; potassium carbonate; silver nitrate;
In
tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2013.03.107