C₂₆H₃₀N₂O₃

Base Information

• Chemical Name: C₂₆H₃₀N₂O₃
• CAS No.: 1449299-54-0
• Molecular Formula: C₂₆H₃₀N₂O₃
• Molecular Weight: 418.536
• Mol file: 1449299-54-0.mol

Synonyms:C₂₆H₃₀N₂O₃

Chemical Property of C₂₆H₃₀N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₀N₂O₃

There total 3 articles about C₂₆H₃₀N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-isobutylphenyl)-N-(quinolin-8-yl)propanamide (1449300-14-4) + ethyl iodoacetae (623-48-3) → C26H30N2O3 (1449299-54-0)

Guidance literature:

With phosphoric acid dibenzyl ester; palladium diacetate; silver carbonate; In tert-Amyl alcohol; at 110 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja406484v

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → C26H30N2O3 (1449299-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 55 °C

2: triethylamine / dichloromethane / 20 °C

3: palladium diacetate; silver carbonate; phosphoric acid dibenzyl ester / tert-Amyl alcohol / 110 °C / Inert atmosphere

With thionyl chloride; phosphoric acid dibenzyl ester; palladium diacetate; triethylamine; silver carbonate; In tert-Amyl alcohol; dichloromethane;

DOI:10.1021/ja406484v

Reference yield:

(+/-)-2-(4-isobutylphenyl)propanoyl chloride (71381-91-4,114978-05-1,115588-20-0,34715-60-1) → C26H30N2O3 (1449299-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: palladium diacetate; silver carbonate; phosphoric acid dibenzyl ester / tert-Amyl alcohol / 110 °C / Inert atmosphere

With phosphoric acid dibenzyl ester; palladium diacetate; triethylamine; silver carbonate; In tert-Amyl alcohol; dichloromethane;

DOI:10.1021/ja406484v

upstream raw materials:

ibuprofen

(+/-)-2-(4-isobutylphenyl)propanoyl chloride

2-(4-isobutylphenyl)-N-(quinolin-8-yl)propanamide

ethyl iodoacetae

Refernces