[2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid

Base Information

• Chemical Name: [2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid
• CAS No.: 143722-25-2
• Molecular Formula: C26H21BN4O2
• Molecular Weight: 432.289
• European Community (EC) Number: 695-658-4
• DSSTox Substance ID: DTXSID00433293
• Nikkaji Number: J629.051E
• Wikidata: Q72515591
• Mol file: 143722-25-2.mol

Synonyms:143722-25-2;[2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid;2-(2-trityl-2H-tetrazol-5-yl)phenylboronic acid;(2-(2-Trityl-2H-tetrazol-5-yl)phenyl)boronic acid;[2-(2-trityltetrazol-5-yl)phenyl]boronic Acid;(2-(2-Trityl-2H-tetrazol-5-yl)phenyl)boronicacid;{2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl}boronic acid;SCHEMBL2564080;DTXSID00433293;LFUCLSFLKKJFQH-UHFFFAOYSA-N;AMY25570;Boronic acid, [2-[2-(triphenylmethyl)-2H-tetrazol-5-yl]phenyl]-;AKOS003622752;AB06409;BS-21468;A3106;CS-0175257;FT-0648392;2-(2-Trityl-2H-tetrazole-5-yl)phenylboronic acid;J-500514;5-(2-boronophenyl)-2-(triphenylmethyl)-2H-tetrazole;5-(2'-Boronophenyl)-2-(triphenylmethyl)-2H-tetrazole;E-2-(1-Pentenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Boronic acid,B-[2-[2-(triphenylmethyl)-2H-tetrazol-5-yl]phenyl]-

Chemical Property of [2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid

Chemical Property:

• Vapor Pressure: 1.03E-19mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 685.156 °C at 760 mmHg
• PKA: 7.97±0.58(Predicted)
• Flash Point: 368.169 °C
• PSA: 84.06000
• Density: 1.208 g/cm³
• LogP: 2.86010
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 432.1757561
• Heavy Atom Count: 33
• Complexity: 560

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Trityl-2H-tetrazol-5-yl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CC=CC=C1C2=NN(N=N2)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)(O)O
• Uses: An intermediate in the synthesis of Losartan

Technology Process of [2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid

There total 3 articles about [2-[2-(Triphenylmethyl)-2H-tetrazol-5-yl]phenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-Phenyl-1H-tetrazole (18039-42-4,3999-10-8) + Triisopropyl borate (5419-55-6) + ammonium chloride + trityl chloride (76-83-5) → 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid (143722-25-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; water; isopropyl alcohol;

Reference yield:

2-trityl-5-phenyl-2H-tetrazole (87268-78-8) → 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid (143722-25-2)

Guidance literature:

2-trityl-5-phenyl-2H-tetrazole; With n-butyllithium; at -20 - 10 ℃; for 1h;

With Triisopropyl borate; at -25 - 10 ℃; for 1.5h;

Reference yield:

→ 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid (143722-25-2)

Guidance literature:

upstream raw materials:

5-Phenyl-1H-tetrazole

Triisopropyl borate

trityl chloride

2-trityl-5-phenyl-2H-tetrazole

Downstream raw materials:

d2-{2-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-imidazol-4-yl}methanol

5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate

Refernces

• 1、 -. "INSULIN SENSITIVITY WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES". . . Retrieved 2008/06/13.
• 2、 -. "PRODRUGS OF IMIDAZOLE CARBOXYLIC ACIDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.