Technology Process of Methyl (2R,3R)-5,5-dimethoxy-2-[N,N'-(dibenzylcarbonylhydrazino)]-3-hydroxypentanoate
There total 1 articles about Methyl (2R,3R)-5,5-dimethoxy-2-[N,N'-(dibenzylcarbonylhydrazino)]-3-hydroxypentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 86 percent / H2 / (R)-BinapRuBr2 / methanol / 18 h / Ambient temperature
2: 1.) MeZnBr, 2.) LDA / 1.) THF, 0 deg C, 1 h, 2.) THF, -78 deg C, 1 h; -78 deg C, 2.5 h
With
hydrogen; lithium diisopropyl amide; zinc methyl bromide;
[(R)-BINAP]RuBr2;
In
methanol;
DOI:10.1055/s-1998-1921
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at -78 ℃;
DOI:10.1055/s-1998-1921
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / 2,6-lutidine / CH2Cl2 / -78 °C
2: 71 percent / H2, H2O / PtO2 / methanol / Ambient temperature
3: H2, H2O / PtO2 / Ambient temperature
4: KOH, H2O, Dowex 50x4 / methanol / Ambient temperature
With
2,6-dimethylpyridine; potassium hydroxide; Dowex 50X4; water; hydrogen;
platinum(IV) oxide;
In
methanol; dichloromethane;
DOI:10.1055/s-1998-1921