Technology Process of Boc-bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OH
There total 16 articles about Boc-bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Boc-bis[Lys(4-[1-{1-tert-butyl-3,3,5,5-tetraethylpiperazin-2-on-1-yloxy}ethyl]benzoyl)-Gly]-OMe;
With
sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 18h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
Inert atmosphere;
DOI:10.1039/c0ob01047b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: peracetic acid; acetic acid / ethyl acetate / 16 h / 0 - 20 °C / Inert atmosphere
2.1: Cu(OTf)2; copper; 4,4'-di-tert-butyl-2,2'-bipyridine / benzene / 16 h / 75 °C / Inert atmosphere
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.33 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C
3.3: 20 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
5.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
7.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere
7.2: 20 °C / Inert atmosphere
With
4-methyl-morpholine; peracetic acid; Cu(OTf)2; tert.-butyl lithium; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,4'-di-tert-butyl-2,2'-bipyridine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; pentane; benzene;
DOI:10.1039/c0ob01047b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere
4.1: sodium hydroxide / methanol; water / 18 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
With
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; dichloromethane; water;
DOI:10.1039/c0ob01047b