4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID

Base Information

• Chemical Name: 4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID
• CAS No.: 143209-97-6
• Molecular Formula: C9H10 Cl N O2
• Molecular Weight: 199.637
• Mol file: 143209-97-6.mol

Synonyms:2-(4-Chlorophenyl)sarcosine

Chemical Property of 4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID

Chemical Property:

• PSA: 49.33000
• LogP: 2.07600

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-Chlorophenyl)-2-(methylamino)aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID

There total 1 articles about 4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

4-chlorobenzaldehyde (104-88-1) → 2-(p-chlorophenyl)sarcosine (143209-97-6)

Guidance literature:

With pyridine; hydrogenchloride; sodium hydroxide; methylamine hydrochloride; acetic anhydride; In water;

Reference yield: 97.0%

2-(p-chlorophenyl)sarcosine (143209-97-6) → 2-(p-Chlorophenyl)-N-(trifluoroacetyl)-sarcosine (143209-98-7)

Guidance literature:

With trifluoroacetic anhydride; In toluene;

Reference yield:

2-(p-chlorophenyl)sarcosine (143209-97-6) → N-methyl-2-(4-chlorophenyl)-5-phenylpyrrole

Guidance literature:

Multi-step reaction with 2 steps

2: 49 percent / Ac₂O / CH₂Cl₂ / 5 h / Heating

With acetic anhydride; In dichloromethane;

DOI:10.1016/S0040-4020(98)00264-6

upstream raw materials:

4-chlorobenzaldehyde

Downstream raw materials:

2-(p-Chlorophenyl)-N-(trifluoroacetyl)-sarcosine

Refernces