6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate

Base Information

• Chemical Name: 6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate
• CAS No.: 1204322-19-9
• Molecular Formula: C₂₁H₂₁F₃O₃S
• Molecular Weight: 410.457
• Mol file: 1204322-19-9.mol

Synonyms:6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate

Chemical Property of 6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate

There total 1 articles about 6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,α-dibenzylcyclohexanone (7382-11-8) + 1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide (145100-50-1) → 6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate (1204322-19-9)

Guidance literature:

α,α-dibenzylcyclohexanone; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide; In tetrahydrofuran; at -78 - 23 ℃; Inert atmosphere;

DOI:10.1002/anie.200905060

Reference yield: 93.0%

6,6-dibenzylcyclohex-1-enyl trifluoromethanesulfonate (1204322-19-9) → (R)-9a-benzyl-2,3,9,9a-tetrahydro-1H-fluorene (1204322-20-2)

Guidance literature:

With (3aR,8aR)-N,N-dibutyl-4,4,8,8-tetrakis(4-tert-butylphenyl)-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-amine; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 23 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200905060

upstream raw materials:

α,α-dibenzylcyclohexanone

1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide

Downstream raw materials:

(R)-9a-benzyl-2,3,9,9a-tetrahydro-1H-fluorene

Refernces