Ethanone, 1-(4-fluorophenyl)-, oxime, (1E)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(4-fluorophenyl)-, oxime, (1E)- (9CI)
• CAS No.: 158364-41-1
• Molecular Formula: C8H8 F N O
• Molecular Weight: 153.156
• Mol file: 158364-41-1.mol

Synonyms:Ethanone,1-(4-fluorophenyl)-, oxime, (E)-; (1E)-1-(4-Fluorophenyl)ethanone oxime

Chemical Property of Ethanone, 1-(4-fluorophenyl)-, oxime, (1E)- (9CI)

Chemical Property:

• Melting Point: 75.6-76.2 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 239.8±23.0 °C(Predicted)
• PKA: 11.27±0.70(Predicted)
• PSA: 32.59000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.02390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(4-fluorophenyl)-, oxime, (1E)- (9CI)

There total 3 articles about Ethanone, 1-(4-fluorophenyl)-, oxime, (1E)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-fluorophenyl)ethanone (403-42-9) → (E)-1-(4-fluorophenyl)ethan-1-one oxime (158364-41-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; water; Reflux;

DOI:10.1016/j.tetlet.2010.12.090

Reference yield: 98.0%

1-(4-fluorophenyl)ethylamine (403-40-7) → (E)-1-(4-fluorophenyl)ethan-1-one oxime (158364-41-1)

Guidance literature:

With Candida antarctica Lipase type B; urea hydrogen peroxide adduct; ethyl acetate; at 30 ℃; for 1h; under 760.051 Torr; Enzymatic reaction;

DOI:10.1039/c7ob00374a

Reference yield: 5.0%

1-ethynyl-4-fluorobenzene (766-98-3) → 2-(4-fluorophenyl)acetaldehyde oxime (137424-94-3) + (E)-1-(4-fluorophenyl)ethan-1-one oxime (158364-41-1)

Guidance literature:

With hydroxylamine; In 1,4-dioxane; water; at 113 ℃;

DOI:10.1002/anie.200703495

upstream raw materials:

1-ethynyl-4-fluorobenzene

1-(4-fluorophenyl)ethanone

1-(4-fluorophenyl)ethylamine

Downstream raw materials:

C₁₀H₁₁BrFNO

N-(4-fluorophenyl)ethanethioamide

Refernces

• 1、 Dai, Hui-Xiong,Guo, Zi-Qiong,Ma, Biao,Wang, Xing,Wang, Zhen-Yu,Xu, Hui. "C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations". supporting information. p. 9716 - 9719. Retrieved 2021/09/30.
• 2、 Han, Ziwei,Shen, Subo,Zheng, Feng,Hu, Han,Zhang, Jianmin,Zhu, Shizheng. "Copper-catalyzed synthesis of oxime ethers from iminoxy radical (C[dbnd]N–O[rad]) and maleimides via radical addition". supporting information. . Retrieved 2019/09/30.