C₆₅H₈₄N₁₂O₁₁

Base Information

• Chemical Name: C₆₅H₈₄N₁₂O₁₁
• CAS No.: 1334182-30-7
• Molecular Formula: C₆₅H₈₄N₁₂O₁₁
• Molecular Weight: 1209.46
• Mol file: 1334182-30-7.mol

Synonyms:C₆₅H₈₄N₁₂O₁₁

Chemical Property of C₆₅H₈₄N₁₂O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₅H₈₄N₁₂O₁₁

There total 17 articles about C₆₅H₈₄N₁₂O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → C65H84N12O11 (1334182-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 16 h / 20 °C

2: mercury dichloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; In water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201200566

Reference yield:

N-tert-butoxycarbonyl-N’-[6-(tert-butoxycarbonylamino)hexanoyl]-S-methylisothiourea (1334181-88-2) + ((2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazine-1-yl]ethyl}cyclopentyl)acetyl]ornithinamide) (1334181-81-5) → C65H84N12O11 (1334182-30-7)

Guidance literature:

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/cmdc.201100241

Reference yield:

N-(tert-butyloxycarbonyl)-S-methylisothiourea (173998-77-1) → C65H84N12O11 (1334182-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 16 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; In N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201100241

upstream raw materials:

N-(tert-butyloxycarbonyl)-S-methylisothiourea

11-(piperazin-1-yl)-5,11-dihydrodibenzo[b,e]azepin-6-one

C₂₇H₃₁N₃O₄

(S)-Nα-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nδ-phthaloylornithinamide

Downstream raw materials:

(2S)-N^ω-(6-aminohexanoyl)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]argininamide

(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]-N^ω-(6-propanoylaminohexanoyl)argininamide

Refernces

• 1、 Pluym, Nikola,Brennauer, Albert,Keller, Max,Ziemek, Ralf,Pop, Nathalie,Bernhardt, Guenther,Buschauer, Armin. "Application of the guanidine-acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists". . p. 1727 - 1738. Retrieved 2012/01/14.