3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI)
• CAS No.: 157650-27-6
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.137
• Mol file: 157650-27-6.mol

Synonyms:3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI)

Chemical Property of 3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI)

Chemical Property:

• Boiling Point: 328.664 °C at 760 mmHg
• PKA: 12.66±0.10(Predicted)
• Flash Point: 152.571 °C
• PSA: 56.65000
• Density: 1.257 g/cm³
• LogP: 0.55498

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI)

There total 7 articles about 3-Pyridinecarbonitrile,4-(hydroxymethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-tert-butyldimethylsilyloxymethylnicotinonitrile (1620645-96-6) → 3-Cyano-4-hydroxymethylpyridin (157650-27-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;

Reference yield:

3-cyano-4-methylpyridine (5444-01-9) → 3-Cyano-4-hydroxymethylpyridin (157650-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / 30percent H₂O₂ / acetic acid / 1.) 80 deg C, 3 h, 2.) 70-80 deg C, 13 h

2: 21 percent / 0.08 h / 140 °C

3: K₂CO₃ / methanol; H₂O / 5 h / Ambient temperature

With dihydrogen peroxide; potassium carbonate; In methanol; water; acetic acid;

DOI:10.1002/ardp.19943270814

Reference yield:

(3-Cyano)-4-picolylacetat (157650-26-5) → 3-Cyano-4-hydroxymethylpyridin (157650-27-6)

Guidance literature:

With potassium carbonate; In methanol; water; for 5h; Yield given; Ambient temperature;

DOI:10.1002/ardp.19943270814

upstream raw materials:

(3-Cyano)-4-picolylacetat

3-cyano-4-methylpyridine

3-Cyan-4-methylpyridin-1-oxid

3-bromo-pyridine-4-carbaldehyde

Refernces

• 1、 -. "OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS". . . Retrieved 2014/08/07.