methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate

Base Information

• Chemical Name: methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate
• CAS No.: 1354965-48-2
• Molecular Formula: C₂₀H₁₅N₃O₂
• Molecular Weight: 329.358
• Mol file: 1354965-48-2.mol

Synonyms:methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate

Chemical Property of methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate

There total 4 articles about methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

3-bromo-naphthalene-1-carboxylic acid methyl ester (16650-63-8) + phenylacetylene (536-74-3) → methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate (1354965-48-2)

Guidance literature:

With sodium azide; copper(l) iodide; sodium L-ascorbate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In dimethyl sulfoxide; for 18h; Reflux;

Reference yield:

3-bromonaphthalic-1,8-anhydride (24050-49-5) → methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate (1354965-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / 60 °C

1.2: 120 h / 100 °C

1.3: 4 h / 100 °C

2.1: sulfuric acid / 24 h / Reflux

3.1: sodium azide / copper(l) iodide; sodium L-ascorbate; cis-N,N'-dimethyl-1,2-diaminocyclohexane / dimethyl sulfoxide / 18 h / Reflux

With sodium azide; sulfuric acid; sodium hydroxide; copper(l) iodide; sodium L-ascorbate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In dimethyl sulfoxide;

Reference yield:

1,8-Naphthalic anhydride (81-84-5) → methyl 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoate (1354965-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid; bromine; silver sulfate / 6 h / 65 °C

2.1: sodium hydroxide / 60 °C

2.2: 120 h / 100 °C

2.3: 4 h / 100 °C

3.1: sulfuric acid / 24 h / Reflux

4.1: sodium azide / copper(l) iodide; sodium L-ascorbate; cis-N,N'-dimethyl-1,2-diaminocyclohexane / dimethyl sulfoxide / 18 h / Reflux

With sodium azide; sulfuric acid; bromine; silver sulfate; sodium hydroxide; copper(l) iodide; sodium L-ascorbate; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In dimethyl sulfoxide;

upstream raw materials:

3-bromonaphthalic-1,8-anhydride

1,8-Naphthalic anhydride

3-bromo-naphthalene-1-carboxylic acid methyl ester

phenylacetylene

Downstream raw materials:

3-(4-phenyl-1H-1,2,3-triazol-1-yl)-1-naphthoic acid

Refernces