Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
1.2: 2 h / 20 °C
2.1: methanol; sodium hydroxide / 4 h / 20 °C
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / 1,2-dimethoxyethane / 2 h / 120 °C / Microwave irradiation
4.1: N-Bromosuccinimide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C
5.1: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran; diethyl ether / 48 h / 75 °C / Inert atmosphere; Microwave irradiation
6.1: copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 21 h / 130 °C / Inert atmosphere
With
methanol; N-Bromosuccinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; sulfuric acid; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether;