1H-Pyrazole-5-carbonyl chloride, 4-chloro-1-methyl- (9CI)

Base Information

• Chemical Name: 1H-Pyrazole-5-carbonyl chloride, 4-chloro-1-methyl- (9CI)
• CAS No.: 157142-50-2
• Molecular Formula: C5H4 Cl2 N2 O
• Molecular Weight: 179.00406
• Hs Code.: 2933199090
• Mol file: 157142-50-2.mol

Synonyms:4-Chloro-1-methyl-5-pyrazolecarbonylchloride

Chemical Property of 1H-Pyrazole-5-carbonyl chloride, 4-chloro-1-methyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.00964mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 264.6°C at 760 mmHg
• Flash Point: 113.8°C
• PSA: 34.89000
• Density: 1.55g/cm³
• LogP: 1.45250

Purity/Quality:

98%min ^*data from raw suppliers

4-chloro-1-methyl-1H-pyrazole-5-carbonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carbonyl chloride, 4-chloro-1-methyl- (9CI)

There total 1 articles about 1H-Pyrazole-5-carbonyl chloride, 4-chloro-1-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-1-methyl-1H-pyrazole-5-carboxylic acid (84547-83-1) → C5H4Cl2N2O (157142-50-2)

Guidance literature:

With thionyl chloride; at 79 ℃; for 2h;

Reference yield:

C5H4Cl2N2O (157142-50-2) + 4-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)aniline (1431386-76-3) → 4-chloro-N-(4-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)phenyl)-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (920002-74-0) + C5H4Cl2N2O (157142-50-2) → 4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (920002-95-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h; Heating / reflux;

upstream raw materials:

4-chloro-1-methyl-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Refernces