3-Methoxypiperidin-4-amine

Base Information

• Chemical Name: 3-Methoxypiperidin-4-amine
• CAS No.: 156970-92-2
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.19
• DSSTox Substance ID: DTXSID80546491
• Mol file: 156970-92-2.mol

Synonyms:3-methoxypiperidin-4-amine;156970-92-2;4-AMINO-3-METHOXYPIPERIDINE;4-Piperidinamine,3-methoxy-,cis-(9CI);SCHEMBL2489657;DTXSID80546491;AKOS006277806

Chemical Property of 3-Methoxypiperidin-4-amine

Chemical Property:

• PSA: 47.28000
• LogP: 0.35110
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 130.110613074
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

98%min ^*data from raw suppliers

4-AMINO-3-METHOXYPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CNCCC1N

Technology Process of 3-Methoxypiperidin-4-amine

There total 3 articles about 3-Methoxypiperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4R)-3-methoxy-N-[(1R)-1-phenylethyl]piperidin-4-amine → (3S,4R)-3-methoxypiperidin-4-amine (156970-92-2)

Guidance literature:

With 5%-palladium/activated carbon; In methanol; at 55 ℃; for 6h; Inert atmosphere;

Reference yield:

tert-butyl (3S,4R)-3-methoxy-4-{[(1R)-1-phenylethyl]amino}piperidine-1-carboxylate monobutanedioate → (3S,4R)-3-methoxypiperidin-4-amine (156970-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium hydroxide / ethyl acetate; water / 4 h / 55 °C

2: 5%-palladium/activated carbon / methanol / 6 h / 55 °C / Inert atmosphere

With hydrogenchloride; 5%-palladium/activated carbon; sodium hydroxide; In methanol; water; ethyl acetate;

Reference yield:

3-methoxy-4-oxopiperidine-1-carboxylic acid t-butyl ester (1188265-31-7) → (3S,4R)-3-methoxypiperidin-4-amine (156970-92-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl acetamide; acetic acid; dimethyl sulfoxide; / 8 h / 60 °C / 2250.23 Torr / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: hydrogenchloride; sodium hydroxide / ethyl acetate; water / 4 h / 55 °C

3.1: 5%-palladium/activated carbon / methanol / 6 h / 55 °C / Inert atmosphere

With hydrogenchloride; N,N-dimethyl acetamide; 5%-palladium/activated carbon; acetic acid; dimethyl sulfoxide; sodium hydroxide; In methanol; water; ethyl acetate;

upstream raw materials:

3-methoxy-4-oxopiperidine-1-carboxylic acid t-butyl ester

Refernces