5-nitro-2-propoxybenzonitrile

Base Information

• Chemical Name: 5-nitro-2-propoxybenzonitrile
• CAS No.: 82245-67-8
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Mol file: 82245-67-8.mol

Synonyms:5-nitro-2-propoxybenzonitrile

Chemical Property of 5-nitro-2-propoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-nitro-2-propoxybenzonitrile

There total 10 articles about 5-nitro-2-propoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C10H12N2O4 → 5-nitro-2-propoxybenzonitrile (82245-67-8)

Guidance literature:

With copper diacetate; In acetonitrile; at 65 ℃; for 3h;

DOI:10.1039/C6RA24651F

Reference yield:

salicylonitrile (611-20-1) → 5-nitro-2-propoxybenzonitrile (82245-67-8)

Guidance literature:

salicylonitrile; With nitric acid; acetic acid; at 50 - 70 ℃; for 4h;

n-propyl halide; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmcl.2017.06.059

Reference yield:

5-nitro-2-hydroxybenzonitrile (39835-09-1) + propyl bromide (106-94-5) → 5-nitro-2-propoxybenzonitrile (82245-67-8)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃;

upstream raw materials:

4-chloro-3-cyanonitrobenzene

sodium n-propoxide

potassium cyanide

4-nitro-phenol

Downstream raw materials:

5-nitro-2-propoxy-benzoic acid amide

Refernces

• 1、 -. "N-(3-cyano-4-alkoxyphenyl) pyridine carboxamide compound and application thereof". Paragraph 0075-0076. . Retrieved 2017/08/09.
• 2、 Shi, Ailong,Wang, Defa,Wang, He,Wu, Yue,Tian, Haiqiu,Guan, Qi,Bao, Kai,Zhang, Weige. "Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors". . p. 114879 - 114888. Retrieved 2016/12/24.