Technology Process of 1-(3,4-dichlorophenyl)-4-vinyl-1H-1,2,3-triazole
There total 5 articles about 1-(3,4-dichlorophenyl)-4-vinyl-1H-1,2,3-triazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
Sonication;
1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm2003624
- Guidance literature:
-
m,p-dichloroaniline;
With
hydrogenchloride; sodium azide; sodium nitrite;
In
water; acetonitrile;
at 0 - 5 ℃;
for 1.5h;
propargyl alcohol;
With
copper(II) sulphate hydrate;
In
water; tert-butyl alcohol;
at 20 ℃;
for 24h;
1H-1,2,3-triazole-4(5)-carbaldehyde;
Further stages;
DOI:10.1016/j.ejmech.2018.07.018
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Darkness
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
3.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere; Sonication
3.2: 20 °C / Inert atmosphere
With
copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;
1.1: Huisgen cycloaddition / 3.2: Wittig reaction;
DOI:10.1021/jm2003624