1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid

Base Information

• Chemical Name: 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid
• CAS No.: 266338-78-7
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.48
• Mol file: 266338-78-7.mol

Synonyms:1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid

Chemical Property of 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid

There total 5 articles about 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)-N,N-dimethylcyclopentanecarboxamide (266338-74-3) → 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid (266338-78-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

Reference yield:

3-Hydroxy-2,2-dimethylpropanoic acid (4835-90-9) → 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid (266338-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / acetonitrile / 30 h / 20 °C

2: 95 percent / aq. HCl / tetrahydrofuran / 26 h / 20 °C

3: 92 percent / acetonitrile / 25 h / 20 °C

4: 86 percent / aq. HCl / tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile; 1: Addition / 2: Hydrolysis / 3: Addition / 4: Hydrolysis;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

Reference yield:

2-benzyl-3-(dimethylamino)-2-methyl-2H-azirine (114234-21-8) → 1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxilic acid (266338-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / acetonitrile / 30 h / 20 °C

2: 95 percent / aq. HCl / tetrahydrofuran / 26 h / 20 °C

3: 92 percent / acetonitrile / 25 h / 20 °C

4: 86 percent / aq. HCl / tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; acetonitrile; 1: Addition / 2: Hydrolysis / 3: Addition / 4: Hydrolysis;

DOI:10.1002/(SICI)1522-2675(20000119)83:1<233::AID-HLCA233>3.0.CO;2-1

upstream raw materials:

1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)-N,N-dimethylcyclopentanecarboxamide

3-Hydroxy-2,2-dimethylpropanoic acid

2-benzyl-3-(dimethylamino)-2-methyl-2H-azirine

2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]propanoic acid

Downstream raw materials:

1-{1-[1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxamido]cyclopentanecarboxamido}-N,N-dimethylcyclopentanecarboxamide

1-[1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxamido]cyclopentanecarboxilic acid

1-[1-({2-benzyl-2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-1-oxopropyl}amino)cyclopentanecarboxamido]-N,N-dimethylcyclopentanecarboxamide

Refernces