ethyl 5-benzyl-ε-oxothiophen-2-hexanoate

Base Information

• Chemical Name: ethyl 5-benzyl-ε-oxothiophen-2-hexanoate
• CAS No.: 116384-97-5
• Molecular Formula: C₁₉H₂₂O₃S
• Molecular Weight: 330.448
• Mol file: 116384-97-5.mol

Synonyms:ethyl 5-benzyl-ε-oxothiophen-2-hexanoate

Chemical Property of ethyl 5-benzyl-ε-oxothiophen-2-hexanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 5-benzyl-ε-oxothiophen-2-hexanoate

There total 1 articles about ethyl 5-benzyl-ε-oxothiophen-2-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 6-chloro-6-oxohexanoate (1071-71-2) + 2-benzylthiophene (13132-15-5) → ethyl 5-benzyl-ε-oxothiophen-2-hexanoate (116384-97-5)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield: 91.0%

ethyl 5-benzyl-ε-oxothiophen-2-hexanoate (116384-97-5) → 5-benzylthiophen-2-hexanoic acid (116408-91-4)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethylene glycol; at 60 ℃; for 4.5h; Heating;

Reference yield:

ethyl 5-benzyl-ε-oxothiophen-2-hexanoate (116384-97-5) → ω-phenyl undecanoic acid (3343-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 95percent hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 4.5 h / 60 °C / Heating

2: 85 percent / Raney nickel-aluminium alloy / aq. NaOH / 3 h / 90 - 120 °C

With potassium hydroxide; Raney nickel-aluminium alloy; hydrazine hydrate; In sodium hydroxide; ethylene glycol;

upstream raw materials:

ethyl 6-chloro-6-oxohexanoate

2-benzylthiophene

Downstream raw materials:

5-benzylthiophen-2-hexanoic acid

ω-phenyl undecanoic acid

11-phenylundecylalcohol

1-bromo-11-phenylundecane

Refernces