sodium 3-(methoxycarbonyl)benzenesulfonate

Base Information

• Chemical Name: sodium 3-(methoxycarbonyl)benzenesulfonate
• CAS No.: 2565-10-8
• Molecular Formula: C₈H₇O₅S*Na
• Molecular Weight: 238.196
• Mol file: 2565-10-8.mol

Synonyms:sodium 3-(methoxycarbonyl)benzenesulfonate

Chemical Property of sodium 3-(methoxycarbonyl)benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium 3-(methoxycarbonyl)benzenesulfonate

There total 1 articles about sodium 3-(methoxycarbonyl)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + m-sulfobenzoic acid, monosodium salt (17625-03-5) → sodium 3-(methoxycarbonyl)benzenesulfonate (2565-10-8)

Guidance literature:

With hydrogenchloride; for 4h; Reflux;

DOI:10.1016/j.ejmech.2018.03.002

Reference yield: 85.0%

sodium 3-(methoxycarbonyl)benzenesulfonate (2565-10-8) → methyl 3-chlorosulfonylbenzoate (63555-50-0)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1016/j.ejmech.2018.03.002

Reference yield:

sodium 3-(methoxycarbonyl)benzenesulfonate (2565-10-8) → N-hydroxy-3-(3-phenylaminosulfonylphenyl)acrylamide (414864-00-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; thionyl chloride / 40 - 50 °C / Large scale

1.2: 2 h / 0 - 30 °C / Large scale

2.1: potassium borohydride; lithium chloride / tetrahydrofuran / 50 °C / Large scale

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / N,N-dimethyl-formamide / 20 - 30 °C / Large scale

4.1: water; sodium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C / Large scale

5.1: oxalyl dichloride / tetrahydrofuran / 0.5 h / 25 - 35 °C / Large scale

5.2: 0.17 h / 0 - 10 °C / Autoclave; Large scale

With pyridine; thionyl chloride; potassium borohydride; oxalyl dichloride; water; lithium chloride; sodium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; N,N-dimethyl-formamide; 4.1: |Wittig-Horner Reaction;

upstream raw materials:

methanol

m-sulfobenzoic acid, monosodium salt

Downstream raw materials:

3-(hydroxymethyl)-N-phenylbenzenesulfonamide

3-formyl-N-phenylbenzene-1-sulfonamide

C₁₅H₁₃NO₄S

N-hydroxy-3-(3-phenylaminosulfonylphenyl)acrylamide

Refernces

• 1、 Zhao, Chunlong,Zang, Jie,Ding, Qin'ge,Inks, Elizabeth S.,Xu, Wenfang,Chou, C. James,Zhang, Yingjie. "Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors". . p. 282 - 291. Retrieved 2018.
• 2、 -. "A he belli department is suitable for industrial production of synthetic method". Paragraph 0011; 0030; 0031. . Retrieved 2016/10/08.