4-Bromo-2-chlorothiophene

Base Information

• Chemical Name: 4-Bromo-2-chlorothiophene
• CAS No.: 32431-93-9
• Molecular Formula: C4H2BrClS
• Molecular Weight: 197.483
• Hs Code.: 2934999090
• European Community (EC) Number: 834-513-3
• DSSTox Substance ID: DTXSID50369159
• Wikidata: Q72453664
• Mol file: 32431-93-9.mol

Synonyms:4-Bromo-2-chlorothiophene;32431-93-9;4-Bromo-2-chloro-thiophene;SCHEMBL1764309;DTXSID50369159;FEDTVFXCDOSSOK-UHFFFAOYSA-N;MFCD00043884;AKOS006273498;AT16572;BS-22361;CS-0157326;FT-0647061;EN300-86458;A846585

Chemical Property of 4-Bromo-2-chlorothiophene

Chemical Property:

• Vapor Pressure: 0.845mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 188 °C at 760 mmHg
• Flash Point: 67.5 °C
• PSA: 28.24000
• Density: 1.844 g/cm³
• LogP: 3.16400
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 195.87491
• Heavy Atom Count: 7
• Complexity: 68.7

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-chlorothiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC=C1Br)Cl
• Uses: 4-Bromo-2-chlorothiophene is a thiophene derivative used in the preparation of potential hypolipidemic agents.

Technology Process of 4-Bromo-2-chlorothiophene

There total 4 articles about 4-Bromo-2-chlorothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3-dibromo-5-chlorothiophene (60404-19-5) → 4-bromo-2-chlorothiophene (32431-93-9)

Guidance literature:

With acetic acid; zinc; at 100 ℃; for 16h;

Reference yield: 2.5%

5-bromo-2-chlorothiophene (2873-18-9) → 3-bromo-4-chlorothiophene (36155-88-1) + 5-Brom-3-chlorthiophen (32431-92-8) + 4-bromo-2-chlorothiophene (32431-93-9)

Guidance literature:

zeolithe; at 190 ℃; for 7h; Product distribution; other temp.;

Reference yield:

4-bromo-[2]thienyl lithium (19162-81-3) → 4-bromo-2-chlorothiophene (32431-93-9)

Guidance literature:

With hexachloroethane; In diethyl ether; hexane; at -78 ℃; for 0.5h;

upstream raw materials:

5-bromo-2-chlorothiophene

2,3-dibromo-5-chlorothiophene

4-bromo-[2]thienyl lithium

Downstream raw materials:

3-Bromo-5-chloro-thiophene-2-sulfonyl chloride

Refernces

• 1、 -. "Halothenoyl-cyclopropane-1-carboxylic acid derivatives". Page 9. . Retrieved 2010/02/07.
• 2、 Dettmeier, Udo,Eichler, Klaus,Kuehlein, Klaus,Leupold, Ernst Ingo,Litterer, Heinz. "Herstellung von β-Halogenthiophenen durch Isomerisierung von α-Halogenthiophenen an Zeolithkatalysatoren". . p. 470 - 471. Retrieved 2007/10/02.