1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine

Base Information

• Chemical Name: 1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine
• CAS No.: 156215-50-8
• Molecular Formula: C₁₇H₂₆N₂OSi
• Molecular Weight: 302.492
• Mol file: 156215-50-8.mol

Synonyms:1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine

Chemical Property of 1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine

There total 1 articles about 1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) + trimethylsilyl cyanide (7677-24-9) → 1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine (156215-50-8)

Guidance literature:

With zinc(II) iodide; 1.) 0 deg C, 3 h, 2.) 60 deg C, 3 h;

DOI:10.1080/00397919408011753

Reference yield:

1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine (156215-50-8) → fenspiride (5053-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 2 h

2: 69 percent / CH₂Cl₂ / 2 h / Ambient temperature

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

DOI:10.1080/00397919408011753

Reference yield:

1-(2-phenethyl)-4-cyano-4-trimethylsilyloxypiperidine (156215-50-8) → 1-(2-phenylethyl)-4-aminomethyl-4-piperidinol (23808-42-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h;

DOI:10.1080/00397919408011753

upstream raw materials:

1-(2-phenylethyl)-4-piperidinone

trimethylsilyl cyanide

Downstream raw materials:

1-(2-phenylethyl)-4-aminomethyl-4-piperidinol

fenspiride

Refernces