Technology Process of 2-Chloro-2'-hydroxy-3',4'-dimethoxy-5'-chloromethylacetophenone
There total 2 articles about 2-Chloro-2'-hydroxy-3',4'-dimethoxy-5'-chloromethylacetophenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; acetic acid;
1.) Room temp., 2.) 60-70 deg C;
DOI:10.1002/jhet.5570170527
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 70 percent / Aluminium chloride / 1,2-dichloro-ethane / 2 h / 0 °C / 2.) Room temp., 3 h
2: 77 percent / Acetic acid, hydrogen chloride gas / 1.) Room temp., 2.) 60-70 deg C
With
hydrogenchloride; aluminium trichloride; acetic acid;
In
1,2-dichloro-ethane;
DOI:10.1002/jhet.5570170527
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / acetonitrile / 1.5 h / Heating
2: 99 percent / Sodium borohydride / methanol; H2O / 1.) below 20 deg C, 2.) room temp., 1.5 h
3: 73 percent / Benzyltriethylammonium Permanganate / CH2Cl2 / 5 h / 20 °C
4: 61 percent / Aluminium chloride / 1,2-dichloro-ethane / 1.5 h / Heating
5: 71 percent / aniline / pyridine / 2 h / 60 °C
6: 72 percent / Copper powder, quinoline / 1 h / Heating
With
quinoline; sodium tetrahydroborate; aluminium trichloride; benzyl(triethyl)ammoniumpermanganate; copper; aniline;
In
pyridine; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/jhet.5570170527
