Multi-step reaction with 5 steps
1.1: potassium carbonate / water; acetone / 0.5 h / 0 - 20 °C
2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C
3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide / water; acetone / 0 - 20 °C
3.2: 0.5 h / 20 °C
4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
5.2: 2 h / -78 - 20 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; n-butyllithium; trichloroisocyanuric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; water; N,N-dimethyl-formamide; acetone;