Technology Process of N-(1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethyl)formamide
There total 9 articles about N-(1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethyl)formamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thionyl chloride / benzene / 1. 30 deg C, 3/4 h, 2.) reflux, 3 h
2: 77 percent / anhydrous AlCl3 / CH2Cl2 / 3 h / Heating
3: 88 percent / 90percent formic acid, formamide / 3.5 h / 185 - 190 °C
With
aluminium trichloride; formic acid; thionyl chloride; formamide;
In
dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)85107-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
1.2: 10 h / 70 °C / Inert atmosphere
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 10 h / 0 - 25 °C
3.1: hydrazine hydrate / ethanol / 8 h / Reflux
4.1: 12 h / Reflux
With
di-isopropyl azodicarboxylate; iodine; hydrazine hydrate; magnesium; triphenylphosphine;
In
tetrahydrofuran; ethanol;
2.1: |Mitsunobu Displacement;
DOI:10.1039/c3ra45933k