(+)-3R,5S-FLUVASTATIN SODIUM SALT

Base Information

• Chemical Name: (+)-3R,5S-FLUVASTATIN SODIUM SALT
• CAS No.: 155229-75-7
• Molecular Formula: C₂₄H₂₆FNO₄
• Molecular Weight: 411.473
• Mol file: 155229-75-7.mol

Synonyms:6-Heptenoicacid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,[S-[R*,S*-(E)]]-;(3R,5S)-Fluvastatin;(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;

Chemical Property of (+)-3R,5S-FLUVASTATIN SODIUM SALT

Chemical Property:

• Boiling Point: 681.8 °C at 760 mmHg
• PKA: 4.27±0.10(Predicted)
• Flash Point: 366.1 °C
• PSA: 85.52000
• Density: 1.23 g/cm³
• LogP: 3.29340
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Methanol, Water

Purity/Quality:

99% ^*data from raw suppliers

(3R,5S,6E)-7-[3-(4-FLUOROPHENYL)-1-(PROPAN-2-YL)-1H-INDOL-2-YL]-3,5-DIHYDROXYHEPT-6-ENOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A synthetic HMG-CoA reductase inhibitor. Antilipemic.This compound contains residual sodium chloride which is quantified on the certificate of analysis.

Technology Process of (+)-3R,5S-FLUVASTATIN SODIUM SALT

There total 4 articles about (+)-3R,5S-FLUVASTATIN SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fluvastatin sodium (94061-80-0) → fluvastatin (93957-54-1,155229-75-7)

Guidance literature:

With sodium hydrogen sulfate; In water; ethyl acetate;

Reference yield:

→ fluvastatin (93957-54-1,155229-75-7)

Guidance literature:

Reference yield:

fluvastatin sodium → fluvastatin (155229-75-7)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; pH=2 - 3;

upstream raw materials:

fluvastatin sodium

R*,S*-(E)-(+/-)-3,5-dihydroxy-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-6-heptenoic acid tert-butyl ester

Downstream raw materials:

C₂₄H₂₆FNO₃

Refernces

• 1、 -. "Methods for predicting the response to statins". . . Retrieved 2011/10/13.
• 2、 -. "COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE". Page/Page column 53. . Retrieved 2008/06/13.