2-Benzofurylglyoxylic acid

Base Information

• Chemical Name: 2-Benzofurylglyoxylic acid
• CAS No.: 39685-86-4
• Molecular Formula: C₁₀H₆O₄
• Molecular Weight: 190.155
• Mol file: 39685-86-4.mol

Synonyms:benzofuran-2-yl-glyoxylic acid

Chemical Property of 2-Benzofurylglyoxylic acid

Chemical Property:

• Vapor Pressure: 6.74E-05mmHg at 25°C
• Boiling Point: 330.3±24.0 °C(Predicted)
• PKA: 1.94±0.54(Predicted)
• Density: 1.435±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-BENZOFURYLGLYOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzofurylglyoxylic acid

There total 6 articles about 2-Benzofurylglyoxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzo[b]furan-2-yl)ethanone (1646-26-0) → benzofuran-2-yl-glyoxylic acid (39685-86-4)

Guidance literature:

With permanganate(VII) ion;

Reference yield:

Benzofuran-2-carboxylic acid (496-41-3) → benzofuran-2-yl-glyoxylic acid (39685-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride

2: diethyl ether; pyridine

3: aqueous hydrochloric acid

4: aqueous KOH-solution

With pyridine; hydrogenchloride; potassium hydroxide; thionyl chloride; diethyl ether;

DOI:10.1002/hlca.19300130609

Reference yield:

2-benzofuroyl chloride (41717-28-6) → benzofuran-2-yl-glyoxylic acid (39685-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; pyridine

2: aqueous hydrochloric acid

3: aqueous KOH-solution

With pyridine; hydrogenchloride; potassium hydroxide; diethyl ether;

DOI:10.1002/hlca.19300130609

upstream raw materials:

1-(benzo[b]furan-2-yl)ethanone

Benzofuran-2-carboxylic acid

2-benzofuroyl chloride

Downstream raw materials:

2-formylbenzo[b]furan

benzofuran-2-yl-methanol

Benzofuran-2-carboxylic acid

benzofuran-2-carbaldehyde-phenylhydrazone

Refernces

• 1、 Sarodnick,Hilfert,Kempter,Kleinpeter. "Reaction of 2-(halogenomethyl)-quinoxalines and -quinoline with hydroxybenzoic acids and their esters". . p. 714 - 720. Retrieved 2007/10/03.