Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI)

Base Information

• Chemical Name: Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI)
• CAS No.: 155087-28-8
• Molecular Formula: C7H6 N4 O2 S
• Molecular Weight: 210.21314
• Mol file: 155087-28-8.mol

Synonyms:Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI)

Chemical Property of Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI)

Chemical Property:

• Boiling Point: 657.7±65.0 °C(Predicted)
• PKA: 2.67±0.30(Predicted)
• PSA: 144.09000
• Density: 1.803±0.06 g/cm3(Predicted)
• LogP: 1.06520

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,4-Diaminothieno[2,3-d]pyrimidine-6-carboxylic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI)

There total 3 articles about Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2,4-diamino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 2,4-diaminothieno<2,3-d>pyrimidine-6-carboxylate → 2,4-diaminothieno<2,3-d>pyrimidine-6-carboxylic acid (155087-28-8)

Guidance literature:

With sodium hydroxide; at 100 ℃; for 0.25h;

Reference yield:

2,4-diamino-6-chloropyrimidine-5-carbaldehyde (18740-20-0) → 2,4-diaminothieno<2,3-d>pyrimidine-6-carboxylic acid (155087-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / 4 Angstroem MS; K₂CO₃ / dimethylformamide / 2 h / 60 °C

2: NaOH; water / methanol / Heating

With sodium hydroxide; 4 Angstroem MS; water; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570430630

Reference yield:

ethyl 2,4-diaminothieno[2,3-d]pyrimidine-6-carboxylate (924300-87-8) → 2,4-diaminothieno<2,3-d>pyrimidine-6-carboxylic acid (155087-28-8)

Guidance literature:

With sodium hydroxide; water; In methanol; Heating;

DOI:10.1002/jhet.5570430630

upstream raw materials:

ethyl 2,4-diaminothieno[2,3-d]pyrimidine-6-carboxylate

2,4-diamino-6-chloropyrimidine-5-carbaldehyde

Refernces

• 1、 Clark, J.,Shahhet, M. S.,Korakas, D.,Varvounis, G.. "Synthesis of Thienopyrimidines from 4,6-Dichloropyrimidine-5-carbaldehydes". . p. 1065 - 1072. Retrieved 2007/10/02.