Technology Process of 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride
There total 8 articles about 6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-amino-5,6-dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione hydrochloride;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 25 ℃;
for 18h;
With
hydrogenchloride;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetone / 18 h / Heating / reflux
2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Heating / reflux
2.2: 0.5 h / 2 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 2 h
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
4.2: 20 °C / Heating / reflux
5.1: hydrogenchloride; t-butylnitrite; acetic acid / 1,4-dioxane / 3 h / 20 °C
6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 1137.76 Torr
7.1: sodium tetrahydroborate / methanol / 18.5 h / 0 - 20 °C
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; t-butylnitrite; water; hydrogen; potassium carbonate; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 1137.76 Torr
2: sodium tetrahydroborate / methanol / 18.5 h / 0 - 20 °C
With
hydrogenchloride; sodium tetrahydroborate; hydrogen;
palladium 10% on activated carbon;
In
methanol;
