crotaramin

Base Information

• Chemical Name: crotaramin
• CAS No.: 255831-59-5
• Molecular Formula: C₂₁H₂₂O₄
• Molecular Weight: 338.403
• Mol file: 255831-59-5.mol

Synonyms:crotaramin

Chemical Property of crotaramin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of crotaramin

There total 8 articles about crotaramin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-acetyl-5-hydroxy-2,2-dimethylchromene (24672-84-2) + 4-methoxybenzyl iodide (70887-29-5) → crotaramin (255831-59-5)

Guidance literature:

6-acetyl-5-hydroxy-2,2-dimethylchromene; With lithium diisopropyl amide; In tetrahydrofuran; at -30 ℃; for 0.5h;

4-methoxybenzyl iodide; In tetrahydrofuran; at -30 - 0 ℃;

DOI:10.1016/S0031-9422(02)00475-2

Reference yield: 59.0%

3,3-dimethyl acrylaldehyde (107-86-8) + 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one (93435-21-3) → crotaramin (255831-59-5)

Guidance literature:

With pyridine; at 150 ℃;

DOI:10.1016/j.bmcl.2004.05.071

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → crotaramin (255831-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / pyridine / 150 °C

2: 77 percent / LDA / -80 °C

With pyridine; lithium diisopropyl amide;

DOI:10.1016/j.bmcl.2004.05.071

upstream raw materials:

6-acetyl-5-hydroxy-2,2-dimethylchromene

4-methoxybenzyl iodide

3,3-dimethyl acrylaldehyde

1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one

Refernces

• 1、 Tadigoppula, Narender,Korthikunta, Venkateswarlu,Gupta, Shweta,Kancharla, Papireddy,Khaliq, Tanvir,Soni, Awakash,Srivastava, Rajeev Kumar,Srivastava, Kumkum,Puri, Sunil Kumar,Raju, Kanumuri Siva Rama,Wahajuddin,Sijwali, Puran Singh,Kumar, Vikash,Mohammad, Imran Siddiqi. "Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents". . p. 31 - 45. Retrieved 2013/02/25.