Technology Process of methyl 2-(2-chloro-5-methyl-4-(pyridin-3-yl)phenyl)acetate
There total 7 articles about methyl 2-(2-chloro-5-methyl-4-(pyridin-3-yl)phenyl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate;
In
tetrahydrofuran; water; toluene;
at 90 ℃;
for 4h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 4 h / 100 °C
2: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 40 h / 0 - 20 °C
3: tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(I) bromide / acetonitrile / 20 °C
4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; tetrahydrofuran; toluene / 4 h / 90 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; nickel (II) chloride hexahydrate; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; copper(I) bromide;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C
2: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / 90 °C
3: sodium periodate; ruthenium(III) chloride monohydrate; tetra-(n-butyl)ammonium iodide / water; ethyl acetate / 0 - 20 °C
4: thionyl chloride / 4 h / 100 °C
5: sodium tetrahydroborate; nickel (II) chloride hexahydrate / methanol / 40 h / 0 - 20 °C
6: tetrabutylammomium bromide; toluene-4-sulfonic acid; copper(I) bromide / acetonitrile / 20 °C
7: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; tetrahydrofuran; toluene / 4 h / 90 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; sodium periodate; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; nickel (II) chloride hexahydrate; ruthenium(III) chloride monohydrate; sulfuric acid; tetrabutylammomium bromide; nitric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; copper(I) bromide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; toluene; acetonitrile;