C₁₃H₁₉N

Base Information

• Chemical Name: C₁₃H₁₉N
• CAS No.: 1232059-79-8
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.301
• Mol file: 1232059-79-8.mol

Synonyms:C₁₃H₁₉N

Chemical Property of C₁₃H₁₉N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₉N

There total 5 articles about C₁₃H₁₉N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,3R)-3-phenyl-cyclohexanecarboxylic acid amide (1232059-70-9) → C13H19N (1232059-79-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

(R)-3-phenylcyclohexanone (20795-53-3,57344-86-2,113829-97-3,34993-51-6) → C13H19N (1232059-79-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / 1,2-dimethoxyethane; tert-butyl alcohol / 0 - 20 °C

2.1: water; sulfuric acid / Reflux

3.1: triethylamine / tetrahydrofuran / 0 °C

3.2: 1 h / 0 °C

3.3: 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.2: Cooling with ice

With lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; water; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; tert-butyl alcohol;

Reference yield:

C13H15N (1232059-56-1) → C13H19N (1232059-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sulfuric acid / Reflux

2.1: triethylamine / tetrahydrofuran / 0 °C

2.2: 1 h / 0 °C

2.3: 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.2: Cooling with ice

With lithium aluminium tetrahydride; sulfuric acid; water; triethylamine; In tetrahydrofuran;

upstream raw materials:

(1S,3R)-3-phenyl-cyclohexanecarboxylic acid amide

(R)-3-phenylcyclohexanone

C₁₃H₁₅N

C₁₃H₁₆O₂

Downstream raw materials:

C₃₁H₄₆N₆O₃S

C₂₄H₃₀N₄O₃

C₁₉H₂₃N₃O₃

C₃₀H₄₃N₅O₄

Refernces

• 1、 -. "NEW CCR2 ANTAGONISTS". Page/Page column 73. . Retrieved 2011/12/14.
• 2、 -. "CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD". Page/Page column 76. . Retrieved 2010/08/05.