(5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide

Base Information

• Chemical Name: (5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide
• CAS No.: 154387-62-9
• Molecular Formula: C₂₃H₃₆N₂O₃
• Molecular Weight: 388.55
• Mol file: 154387-62-9.mol

Synonyms:4-Azaandrost-1-ene-17-carboxamide,N-(1,1-dimethylethyl)-6-hydroxy-3-oxo-, (5a,6a,17b)-;1H-Indeno[5,4-f]quinoline-7-carboxamide,N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-11-hydroxy-4a,6a-dimethyl-2-oxo-,[4aR-(4aa,4bb,6aa,7a,9ab,9ba,11b,11ab)]-; 6a-Hydroxyfinasteride

Chemical Property of (5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide

Chemical Property:

• Refractive Index: 1.539
• Boiling Point: 616.0±55.0 °C(Predicted)
• PKA: 13.51±0.70(Predicted)
• PSA: 85.41000
• Density: 1.121±0.06 g/cm3(Predicted)
• LogP: 3.90150

Purity/Quality:

97% ^*data from raw suppliers

6α-HydroxyFinasteride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Finasteride (M-4 metabolite) A metabolite of Finasteride (F342000) A metabolite of Finasteride (F342000) (M-4 metabolite).

Technology Process of (5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide

There total 2 articles about (5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

finasteride (98319-26-7,140375-21-9,140375-22-0) → 6α-hydroxy-finasteride (154387-62-9)

Guidance literature:

With recombinant cytochrome P₄₅₀ 2D₆; NADPH; In aq. phosphate buffer; at 37 ℃; for 1h; pH=7.4; Enzymatic reaction;

DOI:10.3109/00498254.2013.866298

Reference yield:

finasteride (98319-26-7,140375-21-9,140375-22-0) → C23H36N2O3 + 6α-hydroxy-finasteride (154387-62-9)

Guidance literature:

With recombinant cytochrome P₄₅₀ 3A₄; NADPH; In aq. phosphate buffer; at 37 ℃; for 1h; pH=7.4; Enzymatic reaction;

DOI:10.3109/00498254.2013.866298

upstream raw materials:

finasteride

Refernces