2,4-dichloro-N-phenylbenzamide

Base Information

• Chemical Name: 2,4-dichloro-N-phenylbenzamide
• CAS No.: 6043-39-6
• Molecular Formula: C13H9 Cl2 N O
• Molecular Weight: 266.127
• Mol file: 6043-39-6.mol

Synonyms:Benzanilide,2,4-dichloro- (7CI,8CI); 2,4-Dichlorobenzanilide; NSC 405518; NSC 406945

Chemical Property of 2,4-dichloro-N-phenylbenzamide

Chemical Property:

• Vapor Pressure: 0.000206mmHg at 25°C
• Boiling Point: 327.1°C at 760 mmHg
• Flash Point: 151.6°C
• Density: 1.384g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dichloro-N-phenylbenzamide

There total 10 articles about 2,4-dichloro-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon monoxide (201230-82-2) + 2,4-dichloro-1-iodo-benzene (29898-32-6) + aniline (62-53-3) → 2,4-dichloro-N-phenylbenzamide (6043-39-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 8h; under 750.075 Torr; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.molcata.2014.11.008

Reference yield: 97.0%

2,4-dichlorobenzaldeyhde (874-42-0) + aniline (62-53-3) → (2,4-dichlorophenyl)methanol (1777-82-8) + 2,4-dichloro-N-phenylbenzamide (6043-39-6)

Guidance literature:

aniline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

2,4-dichlorobenzaldeyhde; With yttrium(III) chloride; In toluene; at 20 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In water; toluene; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.09.101

Reference yield: 93.0%

2,4-dichlorobenzaldeyhde (874-42-0) + aniline (62-53-3) → 2,4-dichloro-N-phenylbenzamide (6043-39-6)

Guidance literature:

With sodium hypochlorite; tetra(n-butyl)ammonium hydrogensulfate; at 120 ℃; for 12h;

DOI:10.1016/j.tet.2011.08.091

upstream raw materials:

pyridine N-oxide

2,4-Dichloro-N-phenyl-benzimidoyl chloride

phenyl isocyanate

1,3-Dichlorobenzene

Downstream raw materials:

4-[1-(2,4-dichloro-phenyl)-vinyl]-N,N-dimethyl-aniline

C₃₁H₂₃Cl₂N₂O₃PS

C₂₀H₁₄Cl₂N₄O₅S

C₂₀H₁₆Cl₂N₄O₄S

Refernces

• 1、 Tinnis, Fredrik,Stridfeldt, Elin,Lundberg, Helena,Adolfsson, Hans,Olofsson, Berit. "Metal-free n -arylation of secondary amides at room temperature". supporting information. p. 2688 - 2691. Retrieved 2015/06/16.
• 2、 Urbán, Béla,Papp, Máté,Srankó, Dávid,Skoda-F?ldes, Rita. "Phosphine-free atmospheric carbonylation of aryl iodides with aniline derivatives in the presence of a reusable silica-supported palladium catalyst". . p. 150 - 157. Retrieved 2015/02/19.