1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid

Base Information

• Chemical Name: 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid
• CAS No.: 141944-77-6
• Molecular Formula: C₂₅H₂₅FN₄O₃
• Molecular Weight: 448.497
• Mol file: 141944-77-6.mol

Synonyms:1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid

Chemical Property of 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid

There total 5 articles about 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (68077-26-9) + 1-benzyl-2-(cyanomethyl)piperazine (141944-72-1) → 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid (141944-77-6)

Guidance literature:

In various solvent(s); at 110 ℃; for 24h;

DOI:10.1002/jhet.5570290108

Reference yield:

4-Benzyl-3-cyanomethyl-piperazine-1-carboxylic acid 1-chloro-ethyl ester → 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid (141944-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1 h / Heating

2: 86 percent / various solvent(s) / 24 h / 110 °C

With methanol; In various solvent(s);

DOI:10.1002/jhet.5570290108

Reference yield:

2-chloromethyl-1,4-bis(phenylmethyl)piperazine (24225-89-6) → 1-ethyl-6-fluoro-7-<3-(cyanomethyl)-4-benzyl-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecaboxylic acid (141944-77-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / ethanol; H₂O / 4 h / Heating

2: 1,2-dichloro-ethane / 1 h / Heating

3: methanol / 1 h / Heating

4: 86 percent / various solvent(s) / 24 h / 110 °C

With methanol; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1002/jhet.5570290108

upstream raw materials:

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-benzyl-2-(cyanomethyl)piperazine

2-chloromethyl-1,4-bis(phenylmethyl)piperazine

1,4-dibenzyl-2-hydroxypiperazine

Refernces