N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride

Base Information

• Chemical Name: N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride
• CAS No.: 50656-03-6
• Molecular Formula: C₁₉H₁₅ClN₂
• Molecular Weight: 306.794
• Mol file: 50656-03-6.mol

Synonyms:N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride

Chemical Property of N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride

There total 7 articles about N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

N'-phenyl-1,1-biphenyl-4-carbohydrazide (1448231-27-3) → N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride (50656-03-6)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 20 ℃; for 14h; Reflux;

DOI:10.3184/174751913X13570601346457

Reference yield:

(E)-1-([1,1′-biphenyl]-4-ylmethylene)-2-phenylhydrazine (7253-66-9) → N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride (50656-03-6)

Guidance literature:

With N-chloro-succinimide; 1-(methylthio)decane; In dichloromethane; N,N-dimethyl-formamide; at -78 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0039-1690102

Reference yield:

4-Phenylbenzaldehyde (3218-36-8) → N-phenyl-1,1-biphenyl-4-ylcarbohydrazonoyl chloride (50656-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 60 °C / Inert atmosphere

2: N-chloro-succinimide; 1-(methylthio)decane / dichloromethane; N,N-dimethyl-formamide / 4 h / -78 - 20 °C / Inert atmosphere

With N-chloro-succinimide; 1-(methylthio)decane; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-0039-1690102

upstream raw materials:

4-biphenyl-carboxylic acid chloride

phenylhydrazine

N'-phenyl-1,1-biphenyl-4-carbohydrazide

4-Phenylbenzaldehyde

Downstream raw materials:

3-(1,1-biphenyl-4-yl)-4-[2-(3,4-dimethoxybenzylidene)hydrazinyl]-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

C₃₁H₂₂N₆O₂

C₂₈H₂₀N₆O

C₂₈H₂₀N₆S

Refernces

• 1、 Shurrab, Nabil Kh.,El-Louh, Ali K.,Al-Meghari, Iyad M.,Ferrwanah, Abed El Rahman. "Synthesis of a new series of biphenyl-substituted, fused 1,2,4-triazoles by oxidative cyclisation and Dimroth rearrangement". . p. 91 - 94. Retrieved 2013/04/24.