5-isopropyl-1-phenylbarbituric acid

Base Information

• Chemical Name: 5-isopropyl-1-phenylbarbituric acid
• CAS No.: 19110-07-7
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.266
• Mol file: 19110-07-7.mol

Synonyms:5-isopropyl-1-phenylbarbituric acid

Chemical Property of 5-isopropyl-1-phenylbarbituric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-isopropyl-1-phenylbarbituric acid

There total 6 articles about 5-isopropyl-1-phenylbarbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-phenyl-pyrimidine-2,4,6-trione (15018-50-5) + acetone (67-64-1) → 5-isopropyl-1-phenylbarbituric acid (19110-07-7)

Guidance literature:

With hydrogen; platinum on activated charcoal; In acetic acid; for 20h; under 2585.74 Torr; Further Variations:; Reaction partners; Solvents; Product distribution;

DOI:10.1016/S0040-4039(01)00621-9

Reference yield:

C13H12N2O3 (207602-44-6) → 5-isopropyl-1-phenylbarbituric acid (19110-07-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 1654.92 Torr;

DOI:10.1016/j.bmc.2013.12.010

Reference yield:

1-phenyl-pyrimidine-2,4,6-trione (15018-50-5) → 5-isopropyl-1-phenylbarbituric acid (19110-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h / 0 °C / Sonication

2: 5%-palladium/activated carbon; hydrogen / methanol / 5 h / 20 °C / 1654.92 Torr

With 5%-palladium/activated carbon; hydrogen; In methanol;

DOI:10.1016/j.bmc.2013.12.010

upstream raw materials:

diethyl isopropylmalonate

phenyl carbamate

1-phenyl-pyrimidine-2,4,6-trione

acetone

Downstream raw materials:

N-carbamoyl-2-hydroxy-2-isopropyl-N-phenyl-malonamic acid

N-(α-hydroxy-isovaleryl)-N'-phenyl-urea

N-(α-hydroxy-isovaleryl)-N-phenyl-urea

2-hydroxy-2-isopropyl-N-phenylcarbamoyl-malonamic acid

Refernces

• 1、 Jursic, Branko S.,Neumann, Donna M.. "Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts". . p. 4103 - 4107. Retrieved 2007/10/03.