Technology Process of 3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide
There total 7 articles about 3,4-bis(3,4,5-trimethoxyphenyl)-1-<2-(4-methoxyphenyl)ethyl>pyrrole-2,5-biscarboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
at 25 ℃;
for 2h;
DOI:10.1021/ja982078+
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / PdCl2(PPh3)2, CuI, Bu4NI, Et3N / dimethylformamide / 0.5 h / 70 °C
2: 90 percent / toluene / 48 h / 110 °C
3: 69 percent / Zn, AcOH / 18 h / 25 °C
4: 100 percent / K2CO3 / dimethylformamide / 1.5 h / 110 °C
5: 100 percent / aq. KOH / methanol; dioxane / 72 h / 70 °C
6: 100 percent / i-Pr2NEt, PyBrOP / 2 h / 25 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja982078+
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / PdCl2(PPh3)2, CuI, Bu4NI, Et3N / dimethylformamide / 0.5 h / 70 °C
2: 90 percent / toluene / 48 h / 110 °C
3: 69 percent / Zn, AcOH / 18 h / 25 °C
4: 100 percent / K2CO3 / dimethylformamide / 1.5 h / 110 °C
5: 100 percent / aq. KOH / methanol; dioxane / 72 h / 70 °C
6: 100 percent / i-Pr2NEt, PyBrOP / 2 h / 25 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja982078+
