Technology Process of 2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid
There total 1 articles about 2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methanol; Bromoform; 4-(5-methyl-1,3,4-oxadiazol-2-yl)benzaldehyde;
With
potassium hydroxide;
In
1,4-dioxane;
at 20 ℃;
Cooling with ice;
With
hydrogenchloride;
In
water;
pH=1;
- Guidance literature:
-
2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid;
With
N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane;
for 0.75h;
Inert atmosphere;
Cooling with ice;
N,O-dimethylhydroxylamine*hydrochloride;
In
dichloromethane;
for 3.5h;
Cooling with ice;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 0.75 h / Inert atmosphere; Cooling with ice
1.2: 3.5 h / Cooling with ice
1.3: 0.5 h
2.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C / Inert atmosphere
2.2: 2.42 h / -78 - 20 °C
With
n-butyllithium; N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; hexanes; dichloromethane;