5-Benzyl-2-thiophenesulfonyl chloride

Base Information

• Chemical Name: 5-Benzyl-2-thiophenesulfonyl chloride
• CAS No.: 97272-01-0
• Molecular Formula: C₁₁H₉ClO₂S₂
• Molecular Weight: 272.776
• Mol file: 97272-01-0.mol

Synonyms:5-Benzyl-2-thiophenesulfonyl chloride

Chemical Property of 5-Benzyl-2-thiophenesulfonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-Benzyl-2-thiophenesulfonyl chloride

There total 5 articles about 5-Benzyl-2-thiophenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

phosphorus pentachloride (10026-13-8,874483-75-7) + 2-benzylthiophene (13132-15-5) + 5-benzyl-2-thiophenesulfonic acid (166964-14-3) → 5-Benzyl-2-thiophenesulfonyl chloride (97272-01-0)

Guidance literature:

With chlorosulfonic acid; In hexane; chloroform; ethyl acetate; trichlorophosphate;

Reference yield: 39.0%

5-benzyl-2-thiophenesulfonic acid (166964-14-3) → 5-Benzyl-2-thiophenesulfonyl chloride (97272-01-0)

Guidance literature:

With phosphorus pentachloride; In trichlorophosphate;

Reference yield: 39.0%

5-benzyl-2-thiophenesulfonic acid (166964-14-3) → 5-Benzyl-2-thiophenesulfonyl chloride (97272-01-0)

Guidance literature:

With phosphorus pentachloride; In trichlorophosphate; at 0 - 50 ℃; for 1h;

upstream raw materials:

2-benzylthiophene

N,N-dimethyl-formamide

5-benzyl-2-thiophenesulfonic acid

phosphorus pentachloride

Refernces

• 1、 -. "Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin". . . Retrieved 2008/06/13.
• 2、 Chan, Ming Fai,Kois, Adam,Verner, Erik J.,Raju, Bore G.,Castillo, Rosario S.,Wu, Chengde,Okunm, Ilya,Stavros, Fiona D.,Balaji. "The discovery and structure - Activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET(B) receptor". . p. 2301 - 2316. Retrieved 2007/10/03.