E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride

Base Information

• Chemical Name: E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride
• CAS No.: 1044509-67-2
• Molecular Formula: C₂₀H₂₂N₄S*ClH
• Molecular Weight: 386.948
• Mol file: 1044509-67-2.mol

Synonyms:E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride

Chemical Property of E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride

There total 1 articles about E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5⁽⁶⁾-carboxamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-N-cyclohexylamidino-1,2-phenylenediamine hydrochloride + 3-(2-thienyl)acrolein (14756-03-7,39511-07-4) → E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5(6)-carboxamidine hydrochloride (1044509-67-2)

Guidance literature:

With p-benzoquinone; In ethanol; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm8000423

Reference yield:

E-N'-cyclohexyl-2-(2-thiophen-2-ylvinyl)-3H-benzimidazole-5(6)-carboxamidine hydrochloride (1044509-67-2) → N-cyclohexyl-3-thia-6,10b-diazacyclopenta[c]fluorene-8-carboxamidine hydrochloride (1044509-74-1) + N-cyclohexyl-3-thia-6,10b-diazacyclopenta[c]fluorene-9-carboxamidine hydrochloride (1044509-81-0)

Guidance literature:

With air; iodine; In ethanol; at 20 ℃; for 6h; Irradiation;

DOI:10.1021/jm8000423

upstream raw materials:

3-(2-thienyl)acrolein

Downstream raw materials:

N-cyclohexyl-3-thia-6,10b-diazacyclopenta[c]fluorene-8-carboxamidine hydrochloride

N-cyclohexyl-3-thia-6,10b-diazacyclopenta[c]fluorene-9-carboxamidine hydrochloride

Refernces